The uptake and elimination of halothane in dogs: A two or multicompartment system? II: Evaluation of wash-in and wash-out curves.
نویسندگان
چکیده
In 14 mongrel dogs wash-in and wash-out curves for halothane were obtained from measurements of arterial blood, mixed venous blood and end-tidal gas. From a certain point in the wash-in period the halothane concentration of arterial blood can be calculated from the halothane concentration in end-tidal gas and the blood-gas partition coefficient for halothane. Analysis of the curves shows that they are composed of two exponential components suggesting the presence of two body compartments. The question of a two-compartment system versus a multi-compartment system in discussed.
منابع مشابه
The uptake and elimination of halothane in dogs: a two- or multicompartment system? I: Gas chromatographic determination of halothane in blood and in inspired and end-tidal gases.
The gas chromatographic determination of volatile organic anaesthetic agents in blood and in respiratory gases is described. The analysis in blood is based on a head space technique. Sampling of inspired and end-tidal gases is carried out by means of a system including a gas sampling valve.
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 47 11 شماره
صفحات -
تاریخ انتشار 1975